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Use of alprazolam should be avoided, or carefully monitored by medical professionals, in individuals with the following conditions:[19][20]

Myasthenia gravis
Acute narrow-angle glaucoma
Severe liver deficiencies (e.g., hepatitis and cirrhosis)
Severe sleep apnea
Pre-existing respiratory depression
Marked neuromuscular respiratory weakness including unstable myasthenia gravis
Acute pulmonary insufficiency
Chronic psychosis
Hypersensitivity or allergy to alprazolam or other drugs in the benzodiazepine class
Borderline personality disorder (may induce suicidality and dyscontrol)[21], however correlation does not imply causation, as these behaviors are seen in unmedicated BPD patients.

WAYNE, N.J.–Lederle Laboratories has begun marketing a generic version of Xanax, Upjohn Co.’s antianxiety agent.

Lederle received Food and Drug Administration approval to market alprazolam tablets, the first company to get clearance for four strengths (0.25 mg., 0.5 mg. and 1 mg. tablets in bottles of 100 and 500; and 2 mg. tablets in bottles of 100). Alprazolam is indicated for managing anxiety disorders or for the short-term relief of symptoms of anxiety.

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