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Billed as "super aspirin" when they first came on the market nearly five years ago, Celebrex and Vioxx were widely touted as safer than other pain relievers. This is particularly relevant to people with osteoarthritis or rheumatoid arthritis who risk severe gastrointestinal bleeding and ulcers from chronic use of the older pain medications, such as aspirin, naproxen, ibuprofen, etc. Celebrex and Vioxx quickly became the alternatives, despite the lingering doubts about their purported safety. Cost has always been an issue, as each drug is about $3 a pill.
Celebrex (celecoxib) and Vioxx (rofecoxib) belong to a class of drugs called Cox-2 inhibitors (coxibs) because they inhibit an enzyme that is mostly responsible for pain and inflammation. Their combined sales now total $4.8 billion a year. As would be expected when any drug reaches blockbuster status, new and improved "second generation" coxibs–Bextra and Prexige–have appeared on the scene. The arrival of these drugs comes at a time when the growing body of evidence about the older coxibs has generated many more questions than answers.
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