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Due to the iodine content of the agent (37.3% by weight), abnormalities in thyroid function are common. Amiodarone is structurally similar to thyroxine (a thyroid hormone), which contributes to the effects of amiodarone on thyroid function. Both under- and overactivity of the thyroid may occur on amiodarone treatment. Measurement of free thyroxine (FT4) alone may be unreliable in detecting these problems and thyroid-stimulating hormone (TSH) should therefore also be checked every 6 months.[10]
Hypothyroidism (slowing of the thyroid, called the Wolff-Chaikoff effect) occurs frequently; in the SAFE trial, which compared amiodarone with other medications for the treatment of atrial fibrillation, biochemical hypothyroidism (as defined by a TSH level of 4.5-10 mU/l) occurred in 25.8% of the amiodarone-treated group as opposed to 6.6% of the control group (taking placebo or sotalol). Overt hypothyrodism (defined as TSH >10 mU/l) occurred at 5.0% compared to 0.3%; most of these (>90%) were detected within the first six months of amiodarone treatment.[11]
Hyperthyroidism (an overactive thyroid, called the Jodbasedow effect) is less common. In the SAFE trial, the increased rate of hyperthyroidism (5.3% compared to 2.4%) was not statistically significant. Most hyperthyroid patients (defined as TSH <0.35 mU/l) were asymptomatic.[11]
Thyroid uptake measurements (I-123 or I-131), which are used to differentiate causes of hyperthyroidism, are generally unreliable in patients who have been taking amiodarone. Because of the high iodine content of amiodarone, the thyroid gland is effectively saturated, thus preventing further uptake of isotopes of iodine. However, the radioactive iodine uptake (nuclear thyroid uptake test) may still be helpful in the diagnosis and management of amiodarone-induced hyperthyroidism.[citation needed]

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Propecia Rally New Zealand officials have received support from the world motorsport body, the Federation Internationale De L’Automobile [FIA] on the new format for April’s round of the World Rally Championship.

The FIA will use the New Zealand event as a key trial for the Mille Pistes system, which they introduced this year but recently made optional for the 2004 season.

Rally New Zealand officials decided to remain with the Mille Pistes format for the event from 16-18 April after considering all options including a return to the traditional two days of reconnaissance and three days competition.

SS10 - Parahi 1 (25.18 kms): Gronholm fastest through SS10; Martin second; Solberg third; Loeb fourth; Rovanpera fifth; Duval sixth; Stohl heads the PCWRC category; Solberg leads the overall event by 14.8secs.

Stage times and overall standings after SS10.

Top ten stage times for SS10:

1. Marcus Gronholm Peugeot 307 WRC 12mins 57.2secs 2. Markko Martin Ford Focus RS WRC 03 +00mins 01.4secs 3. Petter Solberg Subaru Impreza WRC 2004 +00mins 02.8secs 4. Sebastien Loeb Citroen Xsara WRC +00mins 11.9secs 5. Harri Rovanpera Peugeot 307 WRC +00mins 12.6secs 6. Francois Duval Ford Focus RS WRC 03 +00mins 18.5secs 7. Mikko Hirvonen Subaru Impreza WRC 2004 +00mins 20.3secs 8. Carlos Sainz Citroen Xsara WRC +00mins 24.6secs 9. Daniel Carlsson Peugeot 206 WRC +00mins 31.2secs 10. Daniel Sola Mitsubishi Lancer Evo VII +00mins 54.2secs

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BRISTOL, Tenn. — The following was released on Saturday, May 19 and is being repeated.

King Pharmaceuticals, Inc. (NYSE:KG) reported today that data from its Phase III clinical trial evaluating ALTACE([R]) (ramipril) 20mg and the combination of ALTACE 20mg and hydrochlorothiazide (HCT) 25mg were presented this weekend at the American Society of Hypertension, Inc. (ASH) Twenty-Second Annual Scientific Meeting and Exposition (ASH 2007) in Chicago, Illinois. The clinical trial data showed that ALTACE 20mg resulted in significant reductions in systolic blood pressure (SBP) and diastolic blood pressure (DBP). ALTACE 20mg used in combination with HCT 25mg once daily as measured by a semi-automatic digital blood pressure device (office measurements) resulted in a statistically significant greater reduction of both seated DBP and seated SBP compared to monotherapy with HCT 25mg once daily or ALTACE 20mg once daily in patients with Stage 2 Essential Hypertension defined as blood pressure equal to or greater than 160 mmHg SBP or 100 mmHg DBP.

Data from the trial also showed that ALTACE 20mg monotherapy once daily provide significant reductions in mean 24-hour SBP and DBP of 11.4 mmHg and 6.2 mmHg, respectively. Importantly, as compared to office measurements, statistically significant greater reductions in mean 24-hour blood pressure, as measured by ambulatory blood pressure monitoring, were obtained with the combination therapy. Ambulatory blood pressure measurements have been shown to correlate better than office measurements for predicting adverse effects on end organs such as the kidney, heart, or brain. The safety profile of the combination was consistent with current labeling for the individual monotherapy drugs as approved by the U.S. Food and Drug Administration (FDA).

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After doctors and patients began switching to a cheaper generic alternative drug called simvastatin in the tens of thousands, Pfizer launched a campaign including advertisements, lobbying efforts, and a paid speaking tour by Dr. Louis W. Sullivan, a former secretary of the federal Department of Health and Human Services, to discourage the trend.[2]
An independent analysis showed that, at commonly prescribed doses, atorvastatin and simvastatin have no statistically significant differences in reducing cardiovascular morbidity and mortality.[8]

The FDA has approved Pfizer Inc.’s Lipitor to reduce the risk of strokes and heart attacks in patients with diabetes. "Patients with multiple risk factors, including diabetes, face a greater threat of heart attack and …

WASHINGTON — Greater LDL Cholesterol Reduction with VYTORIN Compared to Lipitor Resulted in Greater LDL Cholesterol Goal Attainment

Results from a new clinical study conducted in 1,229 patients with type 2 diabetes mellitus and high cholesterol showed that VYTORIN(R) (ezetimibe/simvastatin) provided superior reduction in LDL "bad" cholesterol compared to Lipitor(R) (atorvastatin) in comparisons of the recommended usual starting doses, according to data presented today at the American Diabetes Association’s (ADA) 66th Annual Scientific Session. The primary efficacy endpoint was the percent change from baseline to the end of the six-week treatment period in LDL cholesterol.

VYTORIN, which contains ezetimibe and simvastatin, is the first and only product approved to treat the two sources of cholesterol by inhibiting the production of cholesterol in the liver and blocking the absorption of cholesterol in the intestine, including cholesterol from food. VYTORIN is marketed as INEGY in many countries outside the U.S.

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Closer monitoring is required for those with a history of cardiovascular disease, stroke, glaucoma and/or seizures as well as those who have hyperthyroidism or are receiving thyroid medication.

In the acute recovery phase after myocardial infarction (e.g. heart attack). As for all tricyclic antidepressants concurrent use, or failure to allow a two week gap, with monoamine oxidase inhibitors (MAO inhibitors, e.g. phenelzine, tranylcypromine, etc.) may precipitate hyperpyretic crises and/or severe convulsions; fatalities have occurred.

^ (2002) in Sweetman SC: Martindale. The complete drug reference, 33, Pharmaceutical Press. ISBN 0-85369-499-0. 
^ Prochazka A, Weaver M, Keller R, Fryer G, Licari P, Lofaso D (1998). “A randomized trial of nortriptyline for smoking cessation.”. Arch Intern Med 158 (18): 2035-9. PMID 9778204. 
^ a b British National Formulary 45 March 2003

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Triphala is a valuable herb gifted to us by Mother Nature with amazing health benefits. It gets its name from two words in Sanskrit ‘tri’ meaning three and ‘phala’ meaning fruit. It is composed of three fruits - amalaki (Emblica officinalis), vibhitaka, (Terminalia belerica) and haritaki (Terminalia chebula).

According to ayurveda, triphala is considered to be the tridoshic rasayan. Thus it helps in balancing the three vital elements i.e. vata, pitta and kapha - Amalaki for pitta, vibhitaka for kapha and haritaki for vata. And these elements are supposed to control the human life.

Properties of triphala depend upon the properties of its individual herbs. So to know better about the benefits of triphala let see its components in brief

Haritaki

Haritaki is mentioned in almost all ayurvedic textbooks. According to Charaka, it is as nourishing and useful as mother’s milk. It also helps enhance the absorption of nutrients in food. It is a yogavahini, which means that it cleanses the channels and is absorbed quickly by the body. It looks after the entire digestive, absorptive, assimilative and excretory process.

Amalaki

Amlaki also commonly known as amla fruit contains the sweet, sour, bitter, astringent and pungent tastes. The only taste missing is salty. Because it contains five out of the six tastes, it is balancing to all three doshas. It is the best rejuvenative herbs.

Amla helps purify toxins from the body, by enhancing food absorption. It also helps in eliminating and relieving constipation. It is an excellent source of Vitamin C, and also contains other absorbable minerals that nourish the skin, the blood and the whole body. Because of its high content of Vitamin C, it is a powerful antioxidant.

Vibhitaka

Vibhitaka is a bitter herb and has beneficial effects in healing of wounds. It is a tonic and a laxative. It can also reduce fevers, and hence it is an antipyretic. It cleanses the nutritive fluid (Rasa Dhatu), the blood, the muscle and the fat tissue.

So now we can have an idea why triphala is so powerful. The three fruits that constitute triphala have remarkable abilities to cleanse impurities, tone the digestive tract, nurture the body and restore health.

Triphala when consumed for a long period helps reduce excess weight. It also promotes good colon health and acts as a laxative without causing cramps or irritation. It gently stimulates the intestinal walls and restores tone to the colon, thus helping in the elimination process, providing a colon cleansing effect.

In addition triphala also improves blood circulation. Consequently it is also effective in persons having high blood pressure.

Benefits of Triphala

Triphala can be used in below health problems:

Constipation Colon cleansing Antioxidant Headaches Uterine support Respiratory support Kidney support Cardio vascular support Liver support Gastrointestinal tract tonifier Intestinal cleansing Bile duct opener Sluggish peristalsis Food assimilation support Serum cholesterol balance Digestive balancer Better circulation

Disclaimer: This article is not meant to provide health advice and is for general information only. Always seek the insights of a qualified health professional before embarking on any health program.

Copyright ? Nick Mutt, All Rights Reserved. If you want to use this article on your website or in your ezine, make all the urls (links) active.

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In the typical house 38% of all lost heat escapes though leaks and cracks in the shell of the building. That’s a lot of heat and money gone with the wind. A particularly drafty house might have the air completely replaced up to 10 times every hour. Ideally the air should only refresh once every hour or two.

Though it can be difficult to find all nooks and crannies where heat is on the way out, hunting them down and plugging them up can be the most cost-efficient way to lower your energy bills. Extra bonus: any steps you take to make your house warmer in winter will also serve to make it cooler in the summer by keeping heat out.

HUNTING FOR LEAKS

You have to be a bit of detective to seek out all the chinks where drafty air is slipping in. Experts recommend using a couple of lit incense sticks for this. Simply close all your doors and windows on a fairly windy day then light your incense. Take a tour of the house, holding your incense near potentially leaky spots to see if a draft is present. You can also pay to have a “blower door” test performed by a contractor.

Some of the more common entry and exit points to look for:

- Around doors and windows

- Cracks in walls (interior and exterior)

- Attic and basement doors

- Chimney damper

- Seal between roofing and chimney

- Seal between siding and eaves

- Spaces around wall switches and outlets

- Spaces around outside taps and any plumbing the penetrates the exterior walls

- Seal between the foundation and sill

- Any place where cables, phone lines or wiring enters house

- Any place that ducting or vents penetrate the walls

The good news is that increasing your home’s energy efficiency by sealing up these energy sucking gaps is the cheapest and single most effective way to save money on your heating bill. Most repairs can be done with weatherstripping and caulking which are both inexpensive.

CAULKING

A caulking gun will take care of all the most conspicuous leaks like those around windows and doors. Make sure to plug up any holes that let cables into the house, any space around taps for the garden, and the often overlooked seals between the house and the roof and foundation. For really large gaps, staple plastic sheets over the space or stuff them with strips of insulation, wood, rubber, sponge or heavy rope first, then seal with caulking. Caulking materials are flexible, paint able and should last up to twenty years.

TIP: Aerosol foam can also be used to seal large gaps like those that can be found at the foundation.

WEATHERSTRIPPING

WINDOWS: Windows that open and close will also need weatherstripping around the sash. Metal stripping is a good choice that lasts a long time and can be used in conjunction with other types of stripping to get a good seal. Viinyl or foam rubber gaskets are also popular easy to work. Felt or foam rubber strips should be attached along edge of the sash that meets with the frame to create a tight seal when window is closed.

TIP: Hanging heavy drapery that blocks the chill is another way to reduce heat loss through your windows.

DOORS: Doors will need weatherstripping around the top and sides as well as a good seal at the bottom. Cheap felt or foam rubber strips work well around door jams to create a snug fit when door is closed. Vinyl or foam rubber gaskets or interlocking jam strips can also be used here. Drafts can be kept from sneaking under doors with an easily installed door sweep or door shoe. You’ll probably have to take your doors off their hinges to do this job properly.

TIP: In addition to weatherstripping all doors that lead outside, be sure to seal any doors leading to unheated or rarely heated spaces like the garage, attic and basement.

BLOCKING OTHER ENERGY SUCKERS

CHIMNEY: make sure damper is closed tightly when you’re not using the fireplace. If smoke can get out, so can warm air! Also check that the flashing is doing its job.

OUTLETS & SWITCHES: seal these with special insulating inserts that block air flow.

LIGHT FIXTURES: check for leaks and caulk or otherwise seal.

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Ephedra is a compound that is often used in weight loss products. It is actually one of the world’s oldest medicines, with documented usage in China occurring over 5,000 years ago. The drug has once again found popularity, this time in America’s search for the perfect weight loss drug. It is known to cause many changes in the body; an increased metabolism, increased weight loss, relaxation of the air passages in the lungs, and increased energy are some of the effects reported. One of the major distributors of ephedra was a weight loss drug that is known as Fen-phen. This drug consists of a combination of ephedra and St. John’s Wort, a natural anti-depressant agent. Over the past few years, plenty of other weight loss drugs on the market also included ephedra. Xenadrine RFA-1, Stacker 2, Stacker 3, and Ripped Fuel all contained ephedra.

However, there is a dark side to ephedra. It has been recently banned for all usage by the Food and Drug Administration of the United States of America. In addition to its weight loss purposes, ephedra also causes some negative side-effects that can be quite severe. Ephedra is known to raise the heart rate, as well as the blood pressure of a person that ingests it. Anybody with high blood pressure, diabetes, or heart disease can be seriously in trouble if they take this supplement. A whopping eight hundred people have reported injury due to this weight loss drug, and a full fifty people have died from it. This includes Steve Bechler, an athlete who pitched for the Baltimore Orioles that took the drug during spring training and lost his life. An autopsy showed that indeed, ephedra had contributed to his death. Ten days after this shocking event, the FDA went into action, banning the use of ephedra in all weight loss supplements. The serious consequences reported by those who were damaged by the drug include hypertension, stroke, heart attacks, seizures, and full-on cardiac arrest.

As you can see, this weight loss supplement’s risks surely outweigh its benefits. If you or someone you know is taking this drug, its crucial to stop taking it. There are many ways to lose weight, and there are definitely other supplements that do not wreak havoc on your body like ephedra does. While the drug is illegal, it is still commonly sold, most often online but at the occasional party store. It’s important to realize exactly what a detriment this drug can be to your health. Fitness should not come at the cost of poor health.

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FORT LAUDERDALE, Fla.–(BUSINESS WIRE)–Oct. 14, 2002

Andrx Corporation (Nasdaq:ADRX) today announced that Judge Barbara S. Jones of the United States District Court for the Southern District of New York has issued a decision in the consolidated trial of AstraZeneca Plc (”Astra”) and four generic pharmaceutical manufacturers, including Andrx. The court ruled that Astra’s patents (Nos. ‘505 and `230) are valid, and that the bioequivalent version of Prilosec(R) developed by Andrx, as well as the products developed by Genpharm, Inc. (”Genpharm”) and Cheminor Drugs, LTD, infringe those patents. The court also determined that the bioequivalent version of Prilosec(R) developed by Kremers Urban Development Co. (”Kudco”) does not infringe the asserted claims of those patents. The court has not yet made any rulings with respect to the `281 patent which was asserted solely against the Andrx product, and has not indicated when such ruling is expected.

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Our world population is aging. In just a few years, half of our world’s population will be over the age of fifty. As with all trends, opportunities arise for some to profit off of the change. A new slew of doctors, known as anti-aging specialists, have emerged and are presenting this new “silver boom” generation with a figurative “fountain of youth”. The resulting changes to this generation are creating a split, which will become more and more obvious as time passes.

For tens of thousands of years, man has aged in the same pattern. He is born, experience puberty in the early teen years, peaks testosterone production by age twenty, then slowly declines in bone and muscle mass, as well as testosterone levels, for the remainder of his life. By age 50, some body functions may suffer as the body begins to break down, and by 75 or 80, the average male passes away. It’s the cycle of life.

Hormone replacement therapy and testosterone supplementation is changing all of this. For the first time in mankind’s history, men are now able to postpone the “collapse” which results from the decline of the body’s natural testosterone production. Men are now able to stand before us at age 40, 50, 60, and beyond, with the vitality, strength, and hormone function of an 18-year old male.

This technology is brand new. And while it was reserved for the rich and vain for its first ten years of existence, it’s suddenly being used by the middle-class. Older men everywhere want to feel like young men again, and are flocking to their doctors, seeking patches and shots to help them be kids again.

What will be the effects of this influx to the fountain of youth? Medically, we don’t know the long-term effects of 40+ years of testosterone supplementation on the human body. Most people who have done so to this point have done so quietly, for obvious reasons. As a society, what will be the effects? What happens when these millions of 50-something men suddenly feel twenty years old again? Will we see higher divorce rates and a restructuring of the traditional family unit? And what are the economic implications? Assuming these men live much longer than anticipated, social security system will certainly take a hit, providing years of retirement funding not originally planned for. And what about the women? Will they follow suit and begin their own macro-trek to the fountain of revisited youth?

It’s an exciting trip we’re entering with this world of artificial hormonization of humans to postpone, or completely avoid, the aging process. Time will tell if time can be postponed successfully or not.

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